Building Next-Generation TCR-TCEs Through High-Titer Expression & Optimized Affinity Maturation
- Achieving high-titer CHO production of soluble TCRs and TCR-TCEs using the WuXian Transient™ expression system
- Optimizing TCR affinity maturation from phage libraries to routinely improve KD by ~10,000-fold (from 10-100 μM)
- Integrating high-throughput expression and affinity maturation to efficiently generate building blocks for next-generation TCR-TCE therapeutics