Sarah Leonard
Vice President, Pre-Clinical Development T-Cypher Bio
Sarah helped to establish T-Cypher and is an experienced immunotherapy scientist with a track record of advancing novel T cell therapeutics from concept to clinic. Before joining T-Cypher, she was Scientist in Residence at Oxford Science Enterprises, creating innovative life science ventures. Prior to this Sarah was at Immunocore where she led a team of scientists to generate novel donor-unrestricted T cell therapeutics against oncology and infectious disease targets. She was also involved in the successful delivery of an HBV-bispecific to clinical trials for the treatment of chronic Hepatitis B. Prior to Immunocore, Sarah held a Translational Research Fellowship with Ovacome at the University of Birmingham, where she worked on novel drugs and biomarkers to predict disease progression and chemo resistance in cancer patients. She has also held a number of post-doctoral positions, including with Janssen Pharmaceuticals where she delivered the pre-clinical package for an epigenetic drug combination that went into an acute myeloid leukaemia clinical trial.
Seminars
Uncover how the field is moving beyond familiar targets like MAGE-A4 and PRAME to identify novel antigens that expand patient reach and improve clinical outcomes. This workshop dives into cutting-edge technologies, non-canonical targets, and next-generation engineering strategies that are redefining TCR therapy. Gain practical insights into building robust discovery pipelines, validating tumor specificity, and designing therapies that stand out in a competitive landscape.
Join this workshop to:
- Explore emerging target spaces including non-canonical antigens, alternative HLA molecules, and strategies to increase prevalence and density for broader patient access
- Find new ways to expedite the target validation process using a broad range of tools
- Apply computational tools to discover and validate targets faster and more accurately
- Design next-generation TCR formats to maximize efficacy and durability of response
