Specificity of Rare High-Affinity Human TCRs Derived from Synthetic Yeast-Based Libraries
- Soluble TCR-based therapeutics can potently and specifically target intracellular tumor antigens via peptide-MHC (pMHC) recognition and T-cell redirection but require high affinity for efficacy
- Yeast-based synthetic TCR libraries overcome barriers in therapeutic development by yielding highly developable and fully human soluble TCRs with high affinities and rare specificity profiles
- We decode and compare the specificity of rare high-affinity human TCRs derived from synthetic libraries with naturally derived TCRs to inform their potential for therapeutic development