Selection of High Affinity T-Cell Receptors from Large Fully Human Pre-Immune Yeast Libraries
Time: 3:00 pm
day: Day 1
Details:
• Soluble TCRs can co-opt peptide-HLA (pHLA) recognition to eradicate virally infected and cancerous cells but require high affinity for efficacy in clinically validated T-cell engager formats
• Native TCR repertoires are pruned by central tolerance, limiting the discovery of high-affinity TCRs against many therapeutic pHLA targets and posing a significant barrier to the development of soluble TCR-based therapeutics
• Designing and selecting the first fully human pre-immune TCR libraries built in yeast, facilitating the rapid and high throughput discovery of diverse high-affinity TCRs that retain target pHLA specificity, providing new opportunities for potent and specific therapeutics
