Garrett Rappazzo

Company: Adimab

Job title: Senior Scientist

Seminars:

Selection of High Affinity T-Cell Receptors from Large Fully Human Pre-Immune Yeast Libraries 3:00 pm

• Soluble TCRs can co-opt peptide-HLA (pHLA) recognition to eradicate virally infected and cancerous cells but require high affinity for efficacy in clinically validated T-cell engager formats • Native TCR repertoires are pruned by central tolerance, limiting the discovery of high-affinity TCRs against many therapeutic pHLA targets and posing a significant barrier to the development…Read more

day: Day 1