Transforming T-Cell Receptor Engineering & Affinity Maturation to Enhance Specificity & Efficacy While Guaranteeing Safety
Time: 1:01 pm
day: Workshop B
Details:
TCR molecules are now being engineered and optimized to increase their efficacy through affinity maturation and modifications. However, it is vital to strike the perfect balance between affinity and specificity to ensure maximum efficacy with minimal cross-reactivity. Discuss the benefits of modified TCRs compared to natural molecules, and best practice to safely improve TCR efficacy.
This workshop will gather experts to discuss:
• Engineering T-cell receptors to increase their specificity and decrease the chance of cross-reactivity and off-target effects
• Boosting TCR efficacy by leveraging affinity maturation while maintaining specificity minimizing off-target toxicity
• Considering the benefits and challenges of engineered TCRs compared to natural TCRs to determine best method for your therapeutic
• Reviewing and balancing the need for TCR optimization for both cell and biologic approaches to equip each modality with optimal TCRs
