Spearheading Discovery & Validation of Novel Targets to Expand Indication & Treatment Potential
Time: 9:01 am
day: Workshop A
Details:
TCR-based therapies open a huge pool of intracellular target antigens that cannot be targeted by other therapeutics, but currently, success has only been seen in a small portion of this target repertoire. Therefore, it is imperative to diversify the range of effective targets, as well as to validate their tumor-specificity to mitigate against off-target effects in healthy tissues. Join this deep dive session to hear case studies on novel target development and collaborate to further efforts to expand the range of effective targets.
This workshop will gather experts to discuss:
• Advancing methods such as mass spectrometry to screen tumor samples and identifying novel antigens which are tumor-specific
• Discussing novel areas with potential for novel targets such as neoantigens and dark genome
• Leveraging bioinformatics and screens to validate tumor-specificity and frequency
• Predicting target peptide prevalence in patients and indications to determine viability for development
