Self-Validating Tools for Functional Pan-HLA Epitope & TCR Discovery
Time: 1:05 pm
day: Day 1
Details:
- Data from our lab demonstrating the need for wet-lab validation/discovery methodologies that do not rely on predictive tools or unproven input
- T-FINDER (T-cell functional identification and (Neo-)antigen discovery of epitopes and receptors) is a modular, plug and-play system for high-throughput interrogation of putative TCR:ligand interactions for both class I and class II HLA presented epitopes
- ESTEL (Epitope-specific T-cell expansion on libraries) is an HLA-agnostic tool for identifying TCRs of interest on a set of putative ligands
