Integrating a Co-Stimulatory CD8 Co-Receptor & a Tailored Switch Receptor to Boost Persistence and Anti-Tumor Activity
Time: 2:15 pm
day: Day 2
Details:
• Identifying inhibitory factors in the tumor microenvironment by large-scale tumor screening and translating these into activating signals through switch receptors
• Leveraging inhibitory switch receptors to boost engraftment during TCR-T cell trafficking
• Equipping cells with a costimulatory CD8 co-receptor to overcome lack of co-stimulatory signaling in the tumor
