8:55 am Chair’s Opening Remarks
Reinventing Manufacturing Capabilities to Equip the Field Prior to Rapid Growth
9:00 am Designing TCR Manufacturing Networks for Scalability
Synopsis
• Establishing scalable manufacturing processes
• Utilizing automated technologies to enable reliable throughput
• Designing end-to-end value chains to deliver high volumes of products
Selecting the Optimal Target Antigen to Create an Effective TCR Therapy
9:30 am Expanding Patient Coverage for TCR-T Therapies by Broadening HLA Type Targeting
Synopsis
• Application of TargetScan discovery platform to diverse HLA types for novel target epitope identification
• Using ReceptorScan to identify lead TCRs for novel HLA epitopes
• Leveraging proprietary human proteome libraries across diverse HLAs to assess potential off-target safety risks for TCRs
10:00 am Creating Effective and Safe TAC T Cell Therapies by Targeting Compartmentalized Surface Antigens in Solid Tumors
Synopsis
• The TAC receptor co-opts the endogenous TCR for efficacious and safe T cell anti-tumor responses without MHC restriction
• Compartmentalized surface antigens add to the repertoire of novel tumor-selective targets
• Development status of TAC T cell products in the treatment of solid tumors
10:30 am Morning Refreshment Break & Networking
Investigating Methods to Increase TCR Efficacy
11:30 am The Novel Platform of Discovery and Engineering TCR Mimic Antibodies to Enhance Therapeutic Index of Efficacy and Safety
Synopsis
• Examining methods to engineer TCR mimic antibodies to magnify specificity for target antigens
• Reviewing the pros and cons of affinity enhanced TCR mimic antibodies to safeguard patient safety
• Escalating affinity to the target peptide as well as the MHC to optimize efficacy
12:00 pm Acknowledging the Advantages of a TCR Bispecific Antibody System
Synopsis
• Creating effective TCR antibodies to expand the target pool
• Adopting an antibody TCR technique to ease manufacturing processes
• Valuing the lack of HLA restrictions with TCR antibody use to reduce off-target toxicities
12:30 pm Lunch Break and Networking
1:30 pm Targeting Solid Tumors Using Neoantigen-Specific TCR-T Cells
Synopsis
• Ziopharm’s proprietary neoantigen-reactive TCR discovery platform
• Translation of TCR-T cells to the clinic for the treatment of solid tumors
• Next generation TCR-T cells co-expressing membrane-bound interleukin-15
Navigating Preclinical & Clinical Hurdles to Advance TCR Therapy Development
2:00 pm Developing Preclinical Models that Effectively Evaluate Safety and Efficacy of TCR-T Cell Therapy
Synopsis
• Assessing cross-reactivity and safety through extensive in vitro assays
• Evaluating efficacy and PD in humanized mouse models
2:30 pm Afternoon Refreshments and Networking
3:00 pm Roundtable: Building Awareness of TCR Therapies to Promote Study Enrolment
Synopsis
• Educating the field on the potency of TCR therapies to increase physician referral
• Promoting these therapies and their clinical trials to aid patient enrolment
• Brainstorming effective methods to spread the word of TCR therapies, especially during the Covid-19 pandemic
3:30 pm HuTCR: a Next-Generation TCR and Epitope Discovery Platform to Design TCR-T Therapies of High Efficacy and Safety
Synopsis
• HuTCR mouse lines carrying human TCRs and multiple HLAs to avoid central tolerance and identify TCRs of high affinity and specificity
• Unbiased in vivo epitope discovery engine to identify naturally processed epitopes across multiple HLA types
• TK-8001, a MAGE-A1 targeting TCR-T therapy for solid tumors
4:00 pm Close of Conference Day Two
