Leah Sibener

Company: 3T Biosciences

Job title: Co-founder, Head of Therapeutic Discovery

Seminars:

Mastermind Session: Looking Beyond HLA2 to Reach Wider Patient Populations 2:00 pm

How do we address broader population needs with regards to cell therapies? Discussing how to address patient needs beyond the HLA2 typeRead more

day: Focus Day

Break Out Audience Discussion: Exploring the Importance of Target Binding Affinity and Avidity for Determining TCR-T Function 10:30 am

Discussing how the binding strength between a TCR and ligand influences the downstream function of the cell Addressing how high affinity TCRs can negatively impact the function of the cell Predicting optimal TCR-T function by measuring cell avidity Improving surface levels of expression of TCRsRead more

day: Focus Day

Identifying TCR Specificity and Cross-Reactivity 10:00 am

• Comprehensively profiling peptide HLAs bound by TCRs using high diversitiy pHLA Libraries (3T-TRACE) • Profiling peptide MHCs of clinical TCRs: an opportunity to improve safety whilst maintaining anti-tumor activity • Selecting lead TCRs using bioinformatics, yeast display & in vitro assays to measure TCR activity & specificityRead more

day: Focus Day