Identifying TCR Specificity and Cross-Reactivity

Time: 10:00 am
day: Focus Day


• Comprehensively profiling peptide HLAs bound by TCRs using high diversitiy pHLA Libraries (3T-TRACE)
• Profiling peptide MHCs of clinical TCRs: an opportunity to improve safety whilst maintaining anti-tumor activity
• Selecting lead TCRs using bioinformatics, yeast display & in vitro assays to measure TCR activity & specificity