Genetic Engineering of T cells to Target Neoantigens in Solid Tumors
Time: 12:10 pm
day: Focus Day
Details:
- Non-viral gene transfer such as the Sleeping Beauty system can be used to express neoantigen-specific TCRs
- T cells can be engineered to target public neoantigens shared between tumors and patients such as KRAS and TP53
- T cells can be engineered to target private neoantigens unique to tumors and patients
